• Add a drop of Placebell in your clinical research

  • Placebell is a tool designed to increase the sensitivity and power of your clinical results to detect a true therapeutic effect by a better Individual Placebo Response characterization.

PLACEBELL in a nutshell

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What could you expect from PLACEBELL

Get an overview of the benefits that Placebell has to offer

Information Level

Placebell makes a step toward the characterization and the prediction of the placebo response and enables collection of more complete, pertinent and robust clinical data on new drugs in clinical development.

Decision making

The magnitude of the placebo response has a negative influence in detecting true, statistically significant superiority, of active compounds compared to placebo. Placebell improves your assay sensitivity and facilitates your decision making process.

Study power

Placebell reduces the Placebo associated variance and thus significantly increases the study power to detect a true therapeutic effect.

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Information Level


By increasing assay sensitivity, you may reduce sample size and thus study duration and also avoid repeating clinical trials that show effects that do not quite reach statistical significance but strongly suggest a clinical effect.


Sample size reduction, and/or more accurate information, ultimately reduce your clinical development cost.

Sample size

Positive impact of Placebell on clinical study power may support sample size reduction.

Basically, we limit the negative impact of the Placebo effect

Because high placebo effect reduces your chance of clinical development sucess

What we do

The current scheme

Formal comparisons between study arms, do not take into account individual patientís placebo response, creating an increased variance of the placebo effect that blurs the results of clinical studies.

The Placebell effect

The Individual Placebo Response (IPR) differs from patient to patient. Placebell provides an Individual Placebo Response (IPR) prediction, then IPR may be used as a baseline covariate. This reduces the variance in both the placebo group and the treatment group.

How does it work?


Patient characteristics are strongly associated with the placebo response. An innovative, placebo-specific questionnaire has been developed that combines information from psychological traits, and personality, with disease information, demographic, and medical history.
proportions given as examples

How does it work

Our process

How does it work


Placebell solution is easy to implement. Basically patients are invited to fill out a questionnaire on paper or directly on a computer. The answers are computed and individual placebo responses calculated.

How does it work
How does it work


Based upon data from robust clinical trials, algorithms have been developed to predict individual placebo response (IPR) in new patients.

At database lock, a detailed report with all patients' individual placebo relative scores is sent to statistician group. This allows them to adjust for individual placebo response (as well as other baseline characteristics).

How does it work
How does it work

IPR : Individual Placebo Response

If stratification is needed, Placebell solution is linked to the Interactive Web Response System, which homogenously balances patients among treatment groups according to their individual scores.

Placebell has been validated in pain and
may be adapted to your needs